Gregory B. Lesinski, Ph.D
The Ohio State University

The Role of microRNA in the Progression of Malignant Melanoma

"We are investigating whether small nucleic acid sequences, called microRNA can serve as markers to predict whether 'borderline' skin lesions will develop into melanoma, the most deadly form of skin cancer. Our preliminary research has shown that two specific microRNA sequences (microRNA-21 and microRNA-155) are more prevalent in biopsies from patients with melanoma when compared to patients with benign, non-cancerous biopsies. We will determine whether microRNA-21 and microRNA-155 make melanoma cells more aggressive and determine if the level of mircoRNA can predict whether borderline skin lesions become cancerous."